Biomechanics based Prediction of Aneurysm Rupture Risk

Developed by Grand Roman Joldes, Senior Research Fellow

Intelligent Systems for Medicine Laboratory and Vascular Engineering Laboratory

The University of Western Australia.


BioPARR (Biomechanics based Prediction of Aneurysm Rupture Risk) is a software system that facilitates the analysis of abdominal aortic aneurisms (AAA) and evaluation of rupture risk using a finite element analysis based approach. Except semi-automatic segmentation of the AAA and intraluminal thrombus (ILT) from medical images, the entire analysis is performed automatically. The system is modular and easily expandable, allows the extraction of information from images of different modalities (CT, MRI) and the simulation of different modelling scenarios.

The software system will allow researchers to perform comparative evaluation of AAA using a standardised approach and will help work towards a translational tool for the clinic. It is free to use, you can download it from here (Note: The software requires the installation of 3D Slicer and Paraview. Installers for the supported versions of these programs are available in this archive.)

The software system consists of a collection of programs and scripts which perform the required steps in the AAA workflow, from image segmentation to geometry creation, meshing, finite element analysis and rupture potential index (RPI) computation (Figure 1). The software is divided into several modules which perform specific tasks and are being run in sequence from a master script (batch) file. Data communication between these modules is performed using files in standard formats; this allows the user flexibility in changing or extending the functionality of the software, by replacing or adding additional modules. The software runs on 64Bit Windows operating systems and has been tested on Windows 7 and 8.

I have created a series of tutorial training videos for each step of the analysis; available from my webpage (click on Software and Tutorials).










Figure 1. Example of RPI computation results. a) Intra-luminal thrombus (ILT) thickness [mm]. b) Normalized diameter. c) Wall strength for a female with family history of AAA [MPa]. d) Rupture Potential Index (RPI) for a female with family history of AAA.








Figure 2. a) Example of geometry. AAA exterior surface in blue, interior surface in yellow and ILT surface in red. b) Example of generated mesh. The AAA wall is meshed using 2 layers of elements (configurable). The ILT is meshed using a minimum of 2 layers of elements (configurable); the element size is increased in the middle of the ILT layer to reduce the number of elements in the mesh. c) Example of generated Abaqus model.


BioPARR was developed through funding by the National Health and Medical Research Council (NHMRC), Grant APP1063986 (Dr. B. J. Doyle, Prof. D. Newby, Prof. P. R. Hoskins, Prof. K. Miller and Prof. A. Lu).

Copyright @2016, Grand Roman Joldes